Searchable abstracts of presentations at key conferences in endocrinology

ea0083ao2 | Adrenal and Cardiovascular | EYES2022

Combining steroid and global metabolome profiling by mass spectrometry with machine learning to investigate metabolic risk in benign adrenal tumours with mild autonomous cortisol secretion

A Prete , L Abdi , M Canducci , A. E. Taylor , L. C. Gilligan , A Albors-Zumel , E van den Brandhof , Y Zhang , K. N. Manolopoulos , P Tino , M Biehl , W. B. Dunn , W Arlt

Background: Benign adrenal tumours are discovered in 3-10% of adults and can be non-functioning (NFAT) or associated with adrenal hormone excess, most frequently mild autonomous cortisol secretion (MACS) defined by the failure to suppress cortisol after 1 mg dexamethasone overnight but lack of distinct signs of Cushing’s syndrome (CS). We found that MACS increases the prevalence and severity of type 2 diabetes and hypertension and primarily affects women (Ann Int Med. 202...